From Guild Wars Wiki

Warning: Running Guild Wars on a non-Windows operating system, or with any other computer which does not meet the system requirements, is completely unsupported by ArenaNet and NCSoft.

Installing Wine on Fedora system

Use the following command to install Wine pre-compiled pakage on Fedora system:

yum install wine

Continue on Guild Wars on Wine to complet the GuildWars client installation.

Fedora notes

Consulte this article for more information.