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Spoiler alert: The following text contains spoilers relating to the story of Guild Wars.

The term antagonist refers to the opponents within the Guild Wars games. They come in two varieties: The main antagonists and the "sub-antagonists." In Guild Wars Prophecies and Guild Wars Nightfall, the main antagonist is not revealed until later and in all three campaigns there is a different focus or a "sub-antagonist" within the storyline. Either group may be referred to as the campaign's antagonist.

The main antagonists of Guild Wars are as follows:

The "sub-antagonists" of Guild Wars are as follows: