Disease

The visual effect of a diseased character: a greenish shroud plagued with black flies surrounding the torso

The visual effect on the health bar of a diseased character: pale green color and four arrows of degeneration

Condition. While suffering from this ailment, you lose Health over time. Disease is contagious between creatures of the same kind.

Concise description: You have -4 Health degeneration. Disease is contagious between creatures of the same kind

— in-game description

Game mechanics

• Like poison, disease is a condition which causes 4 pips of health degeneration to a character and turns the Health bar green. Diseased characters are surrounded by a green mist containing black flies.
• Unlike poison, it can spread between creatures of the same creature type which are adjacent to each other.
  • It is the only condition that transfers between creatures.
  • In most circumstances, an application of Disease affects each creature only once.
• Like poison and bleeding, disease only affects fleshy creatures.

Upgrades

• A Rune of Purity or the inscription "Cast Out the Unclean" will reduce disease duration by 20%.

Countering Disease

• In areas with numerous sources of Disease, you can reduce the threat of an epidemic by:
  • Bringing party-wide condition removal (e.g. Extinguish) to prevent an epidemic. Mystic Corruption with a teardown specifically removes disease.
  • Maintaining Tainted Flesh on party members as much as possible to make them immune and reduce the risk of the condition spreading.
  • Using non-human heroes (Jora, M.O.X, Ogden Stonehealer, Pyre Fierceshot, Vekk, and Zhed Shadowhoof) or henchmen (Brutus, Sheena, and Talon Silverwing).
  • Keeping your party spread out.

Skills that cause disease

Icon	Name	Description						Prof.	Attribute	Campaign
	Avatar of Grenth	Elite Form. (10...74...90 seconds.) Your scythe attacks deal dark damage and steal 0...10...12 Health. You are immune to Disease. Apply Disease to all adjacent foes (3 seconds) when you lose a Dervish enchantment. This skill is disabled for 45 seconds.	0	055	02.002	02020		dervisha	MysticismZ	Nightfall
	Mystic Corruption	Flash Enchantment Spell. (20 seconds.) Initial Effect: all adjacent foes are Diseased (1...2...2 second[s].) Double duration if you are already enchanted. End Effect: party members in earshot lose Disease.	0	1010	0	01010		dervisha	MysticismZ	Nightfall
	Putrid Flesh	Spell. Destroys one of your undead servants. Inflicts Diseased condition (5...13...15 seconds) to foes near this servant.	0	1010	00.250.25¼	0		necromancera	Death MagicZ	Nightfall
	Radiation Field	Ward Spell. (5 seconds.) Causes -4...6 Health degeneration to foes in the area. End effect: inflicts Disease condition (12...20 seconds) to foes in the area.	0	1515	02.002	01212		a	Asura rankZ	Eye of the North
	Rotting Flesh	Spell. Inflicts Diseased condition (10...22...25 seconds).	0	1515	03.003	0033		necromancera	Death MagicZ	Core
	Signet of Infection	Signet. Inflicts Diseased condition 13...20 seconds if target foe is Bleeding.	0	0	01.001	01010		a	Ebon Vanguard rankZ	Eye of the North
	Tainted Flesh	Elite Enchantment Spell. (20...39...44 seconds.) Foes who hit target ally in melee become Diseased (3...13...15 seconds); this ally is immune to Disease.	0	055	01.001	0		necromancera	Death MagicZ	Core
	Virulence	Elite Spell. Inflicts Disease, Poison, and Weakness conditions (3...13...15 seconds). No effect unless this foe already had a condition.	0	055	01.001	01515		necromancera	Death MagicZ	Prophecies
	Yellow Snow	Preparation. Lose one condition. Your next snowball causes Disease ( 10 seconds.) [sic]	0	0	00.750.75¾	01212		a	Z	Core

Related skills

Skills that benefit from disease

Icon	Name	Description						Prof.	Attribute	Campaign
	Foul Feast	Spell. Transfers all conditions from target ally to yourself. You gain 0...36...45 Health and 0...2...2 Energy for each condition transferred. Half recharge if you remove Disease. Cannot self-target.	0	055	00.250.25¼	0044		necromancera	Soul ReapingZ	Eye of the North

Skills with disease-dependent effects

Icon	Name	Description						Prof.	Attribute	Campaign
	Toxicity	Nature Ritual. Creates a level 1...8...10 spirit (30...78...90 second lifespan.) Poisoned or Diseased creatures within range have -2 Health degeneration.	0	1515	055	06060		rangera	Beast MasteryZ	Nightfall

Skills that prevent disease

Icon	Name	Description						Prof.	Attribute	Campaign
	Avatar of Grenth	Elite Form. (10...74...90 seconds.) Your scythe attacks deal dark damage and steal 0...10...12 Health. You are immune to Disease. Apply Disease to all adjacent foes (3 seconds) when you lose a Dervish enchantment. This skill is disabled for 45 seconds.	0	055	02.002	02020		dervisha	MysticismZ	Nightfall
	Tainted Flesh	Elite Enchantment Spell. (20...39...44 seconds.) Foes who hit target ally in melee become Diseased (3...13...15 seconds); this ally is immune to Disease.	0	055	01.001	0		necromancera	Death MagicZ	Core

Skills that specifically remove disease

See also: List of condition removal skills

Icon	Name	Description						Prof.	Attribute	Campaign
	Antidote Signet	Signet. Remove Poison, Disease, and Blindness from yourself, and one additional condition.	0	0	01.001	0044		rangera	Z	Core
	Mystic Corruption	Flash Enchantment Spell. (20 seconds.) Initial Effect: all adjacent foes are Diseased (1...2...2 second[s].) Double duration if you are already enchanted. End Effect: party members in earshot lose Disease.	0	1010	0	01010		dervisha	MysticismZ	Nightfall
	Tainted Flesh	Elite Enchantment Spell. (20...39...44 seconds.) Foes who hit target ally in melee become Diseased (3...13...15 seconds); this ally is immune to Disease.	0	055	01.001	0		necromancera	Death MagicZ	Core

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